abstract：:Resveratrol (3,4',5-trihydroxystilbene) is a member of natural, plant-derived chemicals known as polyphenols and is attracting increased attention due to its diverse health benefits especially in case of cardiovascular disease, cancer, diabetes and neurological problems. Despite impressive gains in diagnosis and treat...

journal_title：Molecular aspects of medicine

authors： Das M,Das DK

更新日期：2010-12-01 00:00:00

abstract：:Polyphenols and consequently many flavonoids have several beneficial actions on human health. However, the actual molecular interactions of polyphenols with biological systems remain mostly speculative. This review addresses the potential mechanisms of action that have been so far identified, as well as the feasibilit...

journal_title：Molecular aspects of medicine

authors： Fraga CG,Galleano M,Verstraeten SV,Oteiza PI

更新日期：2010-12-01 00:00:00

abstract：:The non-structural proteins encoded by the orf-I, II, III, and IV genes of the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) genome, are critical for the modulation of cellular gene expression and T-cell proliferation, the escape from cytotoxic T-cells and natural killer cells, and virus expression. In here, we...

journal_title：Molecular aspects of medicine

authors： Van Prooyen N,Andresen V,Gold H,Bialuk I,Pise-Masison C,Franchini G

更新日期：2010-10-01 00:00:00

abstract：:Advanced thyroid cancer refers to thyroid tumors which are resistant to conventional therapies and do not respond to radioiodine and comprises metastatic or recurrent differentiated cancers, poorly differentiated and anaplastic tumors. Progress in the knowledge of genetic/epigenetic alterations in thyroid cancer cells...

journal_title：Molecular aspects of medicine

authors： Catalano MG,Poli R,Pugliese M,Fortunati N,Boccuzzi G

更新日期：2010-04-01 00:00:00

abstract：:Although colorectal cancer (CRC) is still one of the leading causes of cancer related death in the western hemisphere, new therapeutic options have increased the overall survival rate of advanced disease from 10 to 18-24months during the past decade. The new therapeutics include biological agents as bevacizumab (Avast...

journal_title：Molecular aspects of medicine

authors： Waldner MJ,Neurath MF

更新日期：2010-04-01 00:00:00

abstract：:Angiogenesis is integral to the growth and metastatic spread of tumours, and its targeting is an effective anti-tumour strategy. Currently hundreds of anti-angiogenic therapeutics exist in varying stages of development, a number of which have recently gained US Food and Drug Administration (FDA) approval for the treat...

journal_title：Molecular aspects of medicine

authors： Park D,Dilda PJ

更新日期：2010-02-01 00:00:00

abstract：:Reduced glutathione (GSH) is critical for many cellular processes, and both its intracellular and extracellular concentrations are tightly regulated. Intracellular GSH levels are regulated by two main mechanisms: by adjusting the rates of synthesis and of export from cells. Some of the proteins responsible for GSH exp...

journal_title：Molecular aspects of medicine

authors： Ballatori N,Krance SM,Marchan R,Hammond CL

更新日期：2009-02-01 00:00:00

abstract：:The vitamin D endocrine system plays a central role in mineral ion homeostasis through the actions of the vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], on the intestine, bone, parathyroid gland, and kidney. The main function of 1,25(OH)(2)D(3) is to promote the dietary absorption of calcium and phos...

journal_title：Molecular aspects of medicine

authors： Brown AJ,Slatopolsky E

更新日期：2008-12-01 00:00:00

abstract：:The involvement of many zinc metalloproteinases belonging to the metzincin family with a variety of pathological states raises the possibility of therapeutic intervention using synthetic inhibitors with appropriate selectivity. Knowledge of the catalytic domain 3D-structures for various members of the metzincin family...

journal_title：Molecular aspects of medicine

authors： Yiotakis A,Dive V

更新日期：2008-10-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a global health problem, being the second most common chronic viral infection in the world with a global prevalence of about 3% (about 180 million people). HCV is both an hepatotropic and a lymphotropic virus; and chronic infection could cause, on one hand, chronic hepatitis, cirrh...

journal_title：Molecular aspects of medicine

authors： Craxì A,Laffi G,Zignego AL

更新日期：2008-02-01 00:00:00

abstract：:The aldehyde 4-hydroxynonenal (HNE) is a major end-product of peroxidation of membrane n-6-polyunsaturated fatty acids. Primary reactants for HNE are the amino acids cysteine, histidine and lysine, and quantitatively, proteins and peptides represent the most important group of HNE-targeted biomolecules. HNE-protein ad...

journal_title：Molecular aspects of medicine

authors： Poli G,Biasi F,Leonarduzzi G

更新日期：2008-02-01 00:00:00

abstract：:Natural vitamin E consists of four different tocopherol and four different tocotrienol homologues (alpha,beta, gamma, delta) that all have antioxidant activity. However, recent data indicate that the different vitamin E homologues also have biological activity unrelated to their antioxidant activity. In this review, w...

journal_title：Molecular aspects of medicine

authors： Reiter E,Jiang Q,Christen S

更新日期：2007-10-01 00:00:00

abstract：:Delivery of cytokine genes at the tumor site in pre-clinical models has been shown to recruit host inflammatory cells followed by inhibition of tumor growth. This local effect is often accompanied by systemic protection mediated by the immune system, mainly by CD8(+) T and NK cells. On this basis, cytokine gene-transd...

journal_title：Molecular aspects of medicine

authors： Minuzzo S,Moserle L,Indraccolo S,Amadori A

更新日期：2007-02-01 00:00:00

abstract：:RNA interference (RNAi) has emerged as one of the most important discoveries of the last years in the field of molecular biology. Following clarification of this highly conserved endogenous gene silencing mechanism, RNAi has largely been exploited as a powerful tool to uncover the function of specific genes and to und...

journal_title：Molecular aspects of medicine

authors： Masiero M,Nardo G,Indraccolo S,Favaro E

更新日期：2007-02-01 00:00:00

abstract：:When cells are confronted with an insufficient supply of nutrients in their extracellular fluid, they may begin to cannibalize some of their internal proteins as well as whole organelles for reuse in the synthesis of new components. This process is termed autophagy and it involves the formation of a double-membrane st...

journal_title：Molecular aspects of medicine

authors： Monastyrska I,Klionsky DJ

更新日期：2006-10-01 00:00:00

abstract：:17Beta-estradiol (E2) controls many aspects of human physiology, including development, reproduction and homeostasis, through regulation of the transcriptional activity of its cognate receptors (ERs). The crystal structures of ERs with agonists and antagonists and the use of transgenic animals have revealed much about...

journal_title：Molecular aspects of medicine

authors： Ascenzi P,Bocedi A,Marino M

更新日期：2006-08-01 00:00:00

abstract：:L-Carnitine (L-C) is a naturally occurring quaternary ammonium compound endogenous in all mammalian species and is a vital cofactor for the mitochondrial oxidation of fatty acids. Fatty acids are utilized as an energy substrate in all tissues, and although glucose is the main energetic substrate in adult brain, fatty ...

journal_title：Molecular aspects of medicine

authors： Virmani A,Binienda Z

更新日期：2004-10-01 00:00:00

abstract：:Oxidant-mediated damage and the triggering of oxidant-sensitive transcription factors could be associated with the neurotoxic actions of aluminum, zinc and lead. Aluminum and lead could induce oxidative stress through their capacity to interact with active oxygen species, increasing their oxidant activity, or by affec...

journal_title：Molecular aspects of medicine

authors： Oteiza PI,Mackenzie GG,Verstraeten SV

更新日期：2004-02-01 00:00:00

abstract：:Vitamin E and carotenoids are known to act as antioxidants both in vitro and in vivo. In this review we present a series of studies in healthy subjects and in patients who exhibit either acute or chronic oxidative stress. In the EU-Commission funded VITAGE project we investigated the status and effects of vitamin E an...

journal_title：Molecular aspects of medicine

authors： Winklhofer-Roob BM,Rock E,Ribalta J,Shmerling DH,Roob JM

更新日期：2003-12-01 00:00:00

abstract：:In this mini review we summarize recent studies from our laboratory, which show the involvement of 4-hydroxynonenal (4-HNE) in cell cycle signaling. We demonstrate 4-HNE induced apoptosis in various cell lines is accompanied with c-Jun-N-terminal kinase and caspase-3 activation. Cells exposed to mild, transient, heat ...

journal_title：Molecular aspects of medicine

authors： Awasthi YC,Sharma R,Cheng JZ,Yang Y,Sharma A,Singhal SS,Awasthi S

更新日期：2003-08-01 00:00:00

abstract：:Atherosclerosis is an important source of morbidity and mortality in the developed world. Despite the fact that the association between LDL cholesterol and atherosclerosis has been evident for at least three decades, our understanding of exactly how LDL precipitates atherosclerosis is still in its infancy. At least th...

journal_title：Molecular aspects of medicine

authors： Keaney JF Jr

更新日期：2000-08-01 00:00:00

abstract：:Peroxisomes were long believed to play only a minor role in cellular metabolism but it is now clear that they catalyze a number of important functions. The importance of peroxisomes in humans is stressed by the existence of a group of genetic diseases in man in which one or more peroxisomal functions are impaired. Mos...

journal_title：Molecular aspects of medicine

authors： Wanders RJ,Tager JM

更新日期：1998-04-01 00:00:00

abstract：:Coenzyme Q is uniquely designed as an electron and proton carrier within the lipid phase of membranes. It now appears that this unique chemistry has diverse application to important functions in all cellular membranes. The first function of coenzyme Q was defined in the energy transduction process in mitochondria. New...

journal_title：Molecular aspects of medicine

authors： Crane FL,Navas P

更新日期：1997-01-01 00:00:00

abstract：:The oxidation of low density lipoprotein (LDL) is now commonly regarded as an important early event in atherogenesis. As such there is considerable interest in the ability of antioxidant supplementation to attenuate LDL oxidation and hence atherosclerosis. A majority of studies on LDL antioxidation have focused on alp...

journal_title：Molecular aspects of medicine

authors： Thomas SR,Neuzil J,Stocker R

更新日期：1997-01-01 00:00:00

abstract：:Diabetes mellitus associated with mitochondrial tRNA mutation at position 3243(DM-Mt3243) is a new disease. Patients have a distinctly different picture from MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). During observations at the Saiseikai Central Hospital, the following findings...

journal_title：Molecular aspects of medicine

authors： Suzuki Y,Taniyama M,Muramatsu T,Atsumi Y,Hosokawa K,Asahina T,Shimada A,Murata C,Matsuoka K

更新日期：1997-01-01 00:00:00

abstract：:Six experimental groups of young (7-month-old) and aged (24-32-month-old) rats, underwent different dietary manipulations (i.e. dietary restriction and/or a vitamin E-depleted diet), and their liver mitochondria were assayed for several antioxidants and peroxidation markers. Glutathione levels were affected both by ag...

journal_title：Molecular aspects of medicine

authors： Armeni T,Tomasetti M,Svegliati Baroni S,Saccucci F,Marra M,Pieri C,Littarru GP,Principato G,Battino M

更新日期：1997-01-01 00:00:00

abstract：:Coenzyme Q10 (CoQ10) is a critical adjuvant therapy for patients with congestive heart failure (CHF), even when traditional medical therapy is successful. Adjunctive therapy with Q10 may allow for a reduction of other pharmacological therapies, improvement in quality of life, and a decrease in the incidence of cardiac...

journal_title：Molecular aspects of medicine

authors： Sinatra ST

更新日期：1997-01-01 00:00:00

abstract：:The biosynthetic pathway of the CoQ polyisoprenoid side chain, starting from acetyl-CoA and proceeding through mevalonate and isopentenylpyrophosphate, is the same as that of cholesterol. We performed this study to evaluate whether vastatins (hypocholesterolemic drugs that inhibit HMG-CoA reductase) modify blood level...

journal_title：Molecular aspects of medicine

authors： Bargossi AM,Grossi G,Fiorella PL,Gaddi A,Di Giulio R,Battino M

更新日期：1994-01-01 00:00:00

abstract：:Twenty-one healthy subjects received oral Coenzyme Q10 supplementation in soft capsules of 30 mg t.i.d. for 9 months, followed by a withdrawal period of 3 months. Blood samples were taken before start of supplementation, after 3 and 9 months of supplementation, and finally 3 months after withdrawal. Average blood coen...

journal_title：Molecular aspects of medicine

authors： Folkers K,Moesgaard S,Morita M

更新日期：1994-01-01 00:00:00

abstract：:A human study including 22 volunteers was conducted to investigate the antioxidative effect in blood of dietary coenzyme Q10 supplementation. The levels of alpha-tocopherol, ascorbic acid, lipid peroxidation (measured as TBARS) and the redox status of CoQ10 (reduced CoQ10/total CoQ10) were measured in plasma as marker...

journal_title：Molecular aspects of medicine

authors： Weber C,Jakobsen TS,Mortensen SA,Paulsen G,Hølmer G

更新日期：1994-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been frequently implicated in the initiation and promotion phases of carcinogenesis. Antioxidant enzymes, which can antagonize this process, are lowered in a number of malignancies. The enzyme most commonly decreased is the mitochondrial Mn-containing superoxide dismutase (MnSOD) enc...

journal_title：Molecular aspects of medicine

authors： Borrello S,De Leo ME,Galeotti T

更新日期：1993-01-01 00:00:00

abstract：:Carnosine and related dipeptides such as anserine are naturally-occurring histidine-containing compounds. They are found in several tissues most notably in muscle where they represent an appreciable fraction of the total water-soluble nitrogen-containing compounds. The biological role of these dipeptides are conjectur...

journal_title：Molecular aspects of medicine

authors： Quinn PJ,Boldyrev AA,Formazuyk VE

更新日期：1992-01-01 00:00:00

abstract：:Metastasis is a complex non-stochastic process that is most likely the result of genetic and epigenetic interactions of a wide variety of genes. The search for a single gene which can encompass such a pleiotropic response as to account for the observed phenotypic characteristics of metastatic tumour populations has be...

journal_title：Molecular aspects of medicine

authors： Dear TN,Kefford RF

更新日期：1990-01-01 00:00:00